Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo

Jukka Koponen, Hanna M Kankkonen, J Kannasto, +4

Gene Therapy

Tight ControlHuman RetrovirusImmunologyGene VectorGene Expression +2

Truncated vesicular stomatitis virus G protein improves baculovirus transduction efficiency in vitro and in vivo

Minna U. Kaikkonen, J K Räty, Kari J. Airenne, +3

Gene Therapy

Baculovirus Transduction EfficiencyMolecular VirologyPathogenesisViral PathogenesisImmunology +4

Magnetic resonance imaging of viral particle biodistribution in vivo

J K Räty, Timo Liimatainen, Thomas Wirth, +8

Gene Therapy

EngineeringViral DiagnosticsBiomedical ImagingVirologyMagnetic Resonance Imaging +1

Post-transcriptional regulatory element boosts baculovirus-mediated gene expression in vertebrate cells

Anssi J. Mähönen, Kari J. Airenne, Sanna Purola, +8

Journal of Biotechnology

Transcriptional RegulationMolecular VirologyPost-transcriptional Regulatory ElementImmunologyViral Pathogenesis +6

Structure and genomic organization of a new family of murine retrovirus-related DNA sequences (MuRRS)

Martin Schmidt, Thomas Wirth, Burkhard Kröger, +1

Nucleic Acids Research

No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats

Thomas Wirth, Marko Huotari, Kirsti Laitinen, +2

European Journal of Pharmacology

NeurophysiologyMedicineMicrodialysis StudyNeuropharmacologyAcute Catechol-o-methyltransferase Inhibition +8

Clinical trials for glioblastoma multiforme using adenoviral vectors.

Thomas Wirth, Haritha Samaranayake, Jere T. Pikkarainen, +2

PubMed

Adaptive RadiotherapyNeuro-oncologySurgical OncologyRadiation TherapyMedicine +12

Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor–avidin fusion protein

P. Lehtolainen, Thomas Wirth, Anna Taskinen, +10

Gene Therapy

Proteinlipid InteractionDrug TargetingBiochemistryNatural SciencesDrug Discovery +5

Targeted delivery via avidin fusion protein: Intracellular fate of biotinylated doxorubicin derivative and cellular uptake kinetics and biodistribution of biotinylated liposomes

Suvi K. Soininen, Pauliina Lehtolainen‐Dalkilic, Tanja Karppinen, +12

European Journal of Pharmaceutical Sciences

Cell-based Drug DeliveryNanomedicineDrug TargetingEngineeringDoxorubicin Derivative +8

Clinical significance of apoptotic index in non-small cell lung cancer: correlation with p53, mdm2, pRb and p21WAF1/CIP1 protein expression

Dorota Dworakowska, Ewa Jassem, Jacek Jassem, +9

Journal of Cancer Research and Clinical Oncology

P21waf1/cip1 Protein ExpressionMedicinePathologyBronchial NeoplasmApoptotic Index +7