OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi, +14

Nature

Developmental BiologyKey RegulatorBone Morphogenic ProteinCell SignalingLymphocyte Development +9

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Young‐Yun Kong, Ulrich Feige, Iidiko Sarosi, +17

Nature

InflammationRheumatologyRheumatoid DisorderSclerostinAdjuvant Arthritis +12

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

Hailing Hsu, David L. Lacey, Colin R. Dunstan, +18

Proceedings of the National Academy of Sciences

InflammationOsteoprotegerin LigandSclerostinSignal TransductionOpg Transgenic Mice +12

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

Ji Li, Ildiko Sarosi, Xiaoqiang Yan, +20

Proceedings of the National Academy of Sciences

Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

Hosung Min, Sean Morony, Ildiko Sarosi, +9

The Journal of Experimental Medicine

SclerostinOsteoporosisOrthopaedic SurgeryPrevents Vascular CalcificationBone Morphogenic Protein +15

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Young‐Yun Kong, Ulrich Feige, Iidiko Sarosi, +17

Nature

InflammationRheumatologyRheumatoid DisorderSclerostinAdjuvant Arthritis +12

A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3

Sean Morony, Casey Capparelli, Richard Lee, +4

Journal of Bone and Mineral Research

SclerostinBone ResorptionImmunologyCell DeathBone Resorption Induced +17

Apoptosis during bone-like tissue development in vitro

Maureen P. Lynch, Casey Capparelli, Janet L. Stein, +2

Journal of Cellular Biochemistry

Developmental BiologyBone Morphogenic ProteinBone-like Tissue DevelopmentApoptosisBone Repair +12

Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy.

Casey Capparelli, Paul J. Kostenuik, Sean Morony, +7

PubMed

SclerostinBone ResorptionPlasma PthrpImmunologyPathology +18

OPG and PTH-(1–34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats

Paul J. Kostenuik, Casey Capparelli, Sean Morony, +5

Endocrinology