Targeting CD20+ Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells <i>In Vitro</i> and in NSG Mice

Yaya Chu, Jessica Hochberg, Ashlin Yahr, +5

Cancer Immunology Research

Expbnk-treated MiceImmunologyImmune RegulationCd4 T Cell ResponsesImmunotherapeutics +15

Romidepsin alone or in combination with anti-CD20 chimeric antigen receptor expanded natural killer cells targeting Burkitt lymphoma <i>in vitro</i> and in immunodeficient mice

Yaya Chu, Ashlin Yahr, Brian Z. Huang, +3

OncoImmunology

Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2⁺ pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice

Yaya Chu, Gaurav Nayyar, Susiyan Jiang, +5

Journal for ImmunoTherapy of Cancer

Upregulation of NKG2D ligands in acute lymphoblastic leukemia and non-Hodgkin lymphoma cells by romidepsin and enhanced in vitro and in vivo natural killer cell cytotoxicity

Prakash Satwani, Sejal Bavishi, Aniket Saha, +5

Cytotherapy

Cancer ImmunosurveillanceNon-hodgkin Lymphoma CellsImmunologyAcute Lymphoblastic LeukemiaCell Death +5

Ibrutinib significantly inhibited Bruton’s tyrosine kinase (BTK) phosphorylation,<i>in-vitro</i> proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model

Yaya Chu, Sanghoon Lee, Tishi Shah, +15

OncoImmunology

Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy

Janet Ayello, Jessica Hochberg, Allyson Flower, +5

Experimental Hematology

Cell TherapyMedicineImmunologyRe-engineered K562 CellsCell Replacement Therapy +6

Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity

Meisam Naeimi Kararoudi, Brian P. Tullius, Nitin Chakravarti, +8

Seminars in Hematology

Cancer ImmunosurveillanceEnhanced Antitumor ActivityImmunologyEpigenetic ModificationImmune Checkpoint Inhibitor +7

Synthesis and characterization of SnO2 nanorods

Changlin Zheng, Yaya Chu, Yi Dong, +2

Materials Letters

Materials ScienceSno2 NanorodsEngineeringNanomaterialsNanotechnology +2

Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin

Morgan Anderson-Crannage, Alex M. Ascensión, Olga Ibáñez-Solé, +11

Frontiers in Immunology

Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma

Yaya Chu, Gaurav Nayyar, Nang Kham Su, +7

Journal for ImmunoTherapy of Cancer