Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy

Kazuaki Chayama, Yoshiyuki Suzuki, Masahiro Kobayashi, +12

Hepatology

Viral ReplicationImmunologyHepatitis BPathologyAmino Acid Substitution +16

Genetic Polymorphism of the <i>MxA</i> Gene Promoter and Interferon Responsiveness of Hepatitis C Patients: Revisited by Analyzing Two SNP Sites (–123 and –88) in vivo and in vitro

Minako Hijikata, Shunji Mishiro, Chikara Miyamoto, +3

Intervirology

SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C

Masashi Naito, Atsushi Matsui, Mie Inao, +8

Journal of Gastroenterology

Osteopontin GenePromoter RegionHepatologySclerostinViral Hepatitis +6

Genetic polymorphims in promoter region of osteopontin gene may be a marker reflecting hepatitis activity in chronic hepatitis C patients

Satoshi Mochida, Michie Hashimoto, Atsushi Matsui, +7

Biochemical and Biophysical Research Communications

Osteopontin GenePromoter RegionHepatologyHepatitis ActivityViral Hepatitis +10

In Situ Hybridization AT-Tailing with Catalyzed Signal Amplification for Sensitive and Specific in Situ Detection of Human Immunodeficiency Virus-1 mRNA in Formalin-Fixed and Paraffin-Embedded Tissues

Noriko Nakajima, Petronela Ionescu, Yuko Sato, +5

American Journal Of Pathology

Viral ReplicationEngineeringParaffin-embedded TissuesMedicineHuman Retrovirus +9

Genotype, slow decrease in virus titer during interferon treatment and high degree of sequence variability of hypervariable region are indicative of poor response to interferon treatment in patients with chronic hepatitis type C

Kazuaki Chayama, Akihito Tsubota, Yasuji Arase, +8

Journal of Hepatology

Viral PersistenceHepatologyHepatitis CVirus TiterViral Hepatitis +8

Prevalence of TT virus before and after blood transfusion in patients with chronic liver disease treated surgically for hepatocellular carcinoma

Masahiro Kobayashi, Kazuaki Chayama, Yasuji Arase, +10

Journal of Gastroenterology and Hepatology

Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hypervariable region 1 and interferon sensitivity determining region

Michie Hashimoto, Kazuaki Chayama, Masahiro Kobayashi, +10

Journal of Medical Virology

ImmunologyMolecular BiologyPathologyAmino Acid SubstitutionsViral Persistence +16

Antiviral effect of lymphoblastoid interferon‐alpha on hepatitis C virus in patients with chronic hepatitis type C

Kazuaki Chayama, Yasuji Arase, Isao Koida, +11

Journal of Gastroenterology and Hepatology

Predictive factors in eradicating hepatitis C virus using a relatively small dose of interferon

Mizuho Fukuda, Kazuaki Chayama, Akihito Tsubota, +11

Journal of Gastroenterology and Hepatology

Ifn SensitivityViral PersistenceHepatologyHepatitis CHepatitis C Virus +13