B.J. Ortwerth

High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis.

Ram H. Nagaraj, David R. Sell, Malladi Prabhakaram et al. · Proceedings of the National Academy of Sciences · 1991 · 254 citations · Full text

Ocular Disease, Molecular Biology, Lens Pigmentation +17

Regulation of tissue oxygen levels in the mammalian lens

Richard McNulty, Huan Wang, Richard T. Mathias et al. · The Journal of Physiology · 2004 · 182 citations · Full text

Dissolved Oxygen, Ocular Disease, Ophthalmology +15

The non-oxidative degradation of ascorbic acid at physiological conditions

Gregory Simpson, B.J. Ortwerth · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2000 · 158 citations

Ascorbic Acid, Biochemistry, Physiology +6

Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model

Xingjun Fan, Lixing W. Reneker, Mark E. Obrenovich et al. · Proceedings of the National Academy of Sciences · 2006 · 118 citations

Ocular Disease, Biochemistry, Ophthalmology +15

Ascorbic acid-induced crosslinking of lens proteins: evidence supporting a Maillard reaction

B.J. Ortwerth, P.R. Olesen · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1988 · 113 citations

Lens Proteins, Biochemistry, Ophthalmology +8