J Kirk

Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.

G. M. Mintenig, Miguel A. Valverde, Francisco V. Sepúlveda et al. · PubMed · 1993 · 76 citations

Class Iii, Class Ii, Pharmacotherapy +16

Inhibition of volume-activated I- and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition.

J Kirk, Kiaran Kirk · Journal of Biological Chemistry · 1994 · 71 citations · Full text

Pharmacotherapy, Cellular Physiology, Taurine Release +18

Anion channel blockers inhibit swelling-activated anion, cation, and nonelectrolyte transport in HeLa cells

J. A. Hall, J Kirk, Jennifer R. Potts et al. · American Journal of Physiology-Cell Physiology · 1996 · 66 citations

Activated Transport, Signal Transduction, Osmotic Cell +14

High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines

NSA Stuart, P. A. Philip, Katia Tonkin et al. · British Journal of Cancer · 1992 · 61 citations · Full text

Medicine, Pharmacology, Breast Cancer +10

Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites

J Kirk, S Houlbrook, N Stuart et al. · British Journal of Cancer · 1993 · 42 citations · Full text

Doxorubicin Toxicity, Oxysterol, Biochemistry +9