A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes

Kazuhito Watanabe, Shizuo Narimatsu, Tamihide Matsunaga, +2

Biochemical Pharmacology

Cannabis UseAldehyde DehydrogenaseBiochemistryMedicineLiver Physiology +12

Application of interleukin 12 to antitumor cytokine and gene therapy

Takashi Nishimura, Kazuhito Watanabe, Takashi Yahata, +6

Cancer Chemotherapy and Pharmacology

InflammationCytokineCancer ImmunosurveillanceMedicineImmunology +7

Analysis and pharmacotoxicity of feruloyltyramine as a new constituent and p-coumaroyltyramine in Cannabis sativa L.

Ikuo Yamamoto, Tamihide Matsunaga, H. Kobayashi, +2

Pharmacology Biochemistry and Behavior

Cannabis UseMolecular PharmacologyNew ConstituentCannabis Sativa LPharmacological Study +8

Cannabielsoin as a new metabolite of cannabidiol in mammals

Ikuo Yamamoto, Hiroshi GOHDA, Shizuo Narimatsu, +2

Pharmacology Biochemistry and Behavior

PharmacologyPhysiologyCannabis UseNew Metabolite

cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase

T Matsunaga, Kazuhito Watanabe, Ikuo Yamamoto, +3

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Molecular ResearchCellular EnzymologyBiochemistryAldehyde DehydrogenaseNatural Sciences +7

Interleukin‐12 Augments the Generation of Autologous Tumor‐reactive CD8⁺ Cytotoxic T Lymphocytes from Tumor‐infiltrating Lymphocytes

Soichi Kuge, Kazuhito Watanabe, Koji Makino, +5

Japanese Journal of Cancer Research

Effect of repeated administration of 11-hydroxy-Δ8-tetrahydrocannabinol, an active metabolite of Δ8tetrahydrocannabinol, on the hepatic microsomal drug-metabolizing enzyme system of mice

Kazuhito Watanabe, Aarai Mayumi, Shizuo Narimatsu, +2

Biochemical Pharmacology

Cannabis UseBiochemistryMedicineLiver PhysiologyRepeated Administration +5

CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes.

T Matsunaga, Nobuyuki Kishi, S. Higuchi, +3

PubMed

Redox BiologyToxicological MechanismOxidative StressMolecular PharmacologyHepatotoxicity +18

Tumor-associated glycoantigen, sialyl Lewisa as a target for bispecific antibody-directed adoptive tumor immunotherapy

So Ohta, Hideo Tsukamoto, Kazuhito Watanabe, +5

Immunology Letters

Tumor ImmunologyTumor-associated GlycoantigenMedicineImmunologyTumor Immunity +9

Ion milling of nitrized 18-8 stainless steel

Yoshitake Nishi, Noriyuki Inoue, Kazuhito Watanabe, +2

Journal of Materials Science Letters

Materials EngineeringMaterials ScienceEngineeringCorrosionIon Milling +5