Melvyn Little

A surface expression vector for antibody screening

Frank Breitling, Stefan Dübel, Thomas Seehaus et al. · Gene · 1991 · 305 citations

Surface Expression Vector, Immunology, Antibody Screening +5

Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics

Sergey M Kipriyanov, Gerhard Moldenhauer, Jochen Schuhmacher et al. · Journal of Molecular Biology · 1999 · 194 citations

Oncology, Improved Antigen Binding, Tumor Therapy +10

Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation.

B. Cochlovius, Sergej Kipriyanov, Marike Stassar et al. · PubMed · 2000 · 91 citations

Cell Therapy, Immunology, Pathology +19

Bispecific CD3 × CD19 diabody for T cell-mediated lysis of malignant human B cells

Sergey M. Kipriyanov, Gerhard Moldenhauer, Melvyn Little · International Journal of Cancer · 1998 · 89 citations · Full text

Immunology, Immunologic Mechanism, Antigen Processing +16

Effect of linker sequences between the antibody variable domains on the formation, stability and biological activity of a bispecific tandem diabody

Fabrice Le Gall, Uwe Reusch, Melvyn Little et al. · Protein Engineering Design and Selection · 2004 · 80 citations