Biliary Apotopes and Anti-Mitochondrial Antibodies Activate Innate Immune Responses in Primary Biliary Cirrhosis†

Ana Lleò, Christopher L. Bowlus, Guo–Xiang Yang, +8

Hepatology

Hepatic IL-17 responses in human and murine primary biliary cirrhosis

Ruth Y. Lan, Thucydides L. Salunga, Koichi Tsuneyama, +10

Journal of Autoimmunity

HepatologyBiliary TractLiver PhysiologyImmunologyPathology +9

Natural killer T cells exacerbate liver injury in a transforming growth factor β receptor II dominant-negative mouse model of primary biliary cirrhosis

Ya‐Hui Chuang, Zhe‐Xiong Lian, Guo–Xiang Yang, +8

Hepatology

Adaptive Immune SystemImmunologyImmune RegulationPathologyImmunologic Mechanism +22

Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse

Guo–Xiang Yang, Thomas P. Kenny, Kazuhito Kawata, +11

Journal of Autoimmunity

InflammationCytokineInflammatory DiseaseImmune Cell DevelopmentImmune Regulation +6

Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives

Ya‐Hui Chuang, Zhe‐Xiong Lian, Chun-Mei Cheng, +8

Journal of Autoimmunity

Autoimmune DiseaseHepatologyChemokine Receptor Cxcr3Biliary TractLiver Physiology +11

B Cells Suppress the Inflammatory Response in a Mouse Model of Primary Biliary Cirrhosis

Yuki Moritoki, Weici Zhang, Koichi Tsuneyama, +11

Gastroenterology

Humoral ResponseImmunologyPathologyPrimary Biliary CirrhosisCholangiopathies +18

AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers

Yuki Moritoki, Zhe‐Xiong Lian, Heike Wulff, +7

Hepatology

Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis

Kentaro Kikuchi, Zhe‐Xiong Lian, Yasuhiko Kimura, +10

Journal of Autoimmunity

ImmunogeneticsToll-like Receptor 9Autoimmune DiseaseHepatologyGenetic Polymorphisms +13

B cell depletion therapy exacerbates murine primary biliary cirrhosis

Amy Dhirapong, Ana Lleò, Guo–Xiang Yang, +10

Hepatology

Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis

Masanobu Tsuda, Yoko M. Ambrosini, Weici Zhang, +12

Hepatology