Enhanced Mdm2 activity inhibits pRB function via ubiquitin‐dependent degradation

Chiharu Uchida, Seiichi Miwa, Kyoko Kitagawa, +9

The EMBO Journal

Concordant p53 and <i>DCC</i> alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma

Keizou Ookawa, Michiie Sakamoto, Setsuo Hirohashi, +4

International Journal of Cancer

GeneticsPathologyPolymorphic Dna MarkersLiver MetastasesCancer Biology +14

Retinoic Acid-Inducible Gene-I Is Induced in Endothelial Cells by LPS and Regulates Expression of COX-2

Tadaatsu Imaizumi, Satoko Aratani, Toshihiro Nakajima, +10

Biochemical and Biophysical Research Communications

InflammationTranscriptional RegulationAngiogenesisEndothelial CellsRegulates Expression +8

Transcriptional Activation of the MUC2 Gene by p53

Keizou Ookawa, Toshihiro Kudo, Shu Aizawa, +2

Journal of Biological Chemistry

Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD‐1 and suppression by <i>N</i>‐acetyl‐<scp>l</scp>‐cysteine

Shu Aizawa, Keizou Ookawa, Toshihiro Kudo, +3

Cancer Science

Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations.

Keizou Ookawa, Masayuki Shiseki, Rina Takahashi, +3

PubMed

Emergence of nuclear heparanase induces differentiation of human mammary cancer cells

Tetsuji Nobuhisa, Yoshio Naomoto, Munenori Takaoka, +10

Biochemical and Biophysical Research Communications

Tumor BiologyDevelopmental BiologyMedicineMammary GlandCell Proliferation +5

Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line

Keizou Ookawa, Shigeki Tsuchida, Jun-ichi Adachi, +1

Oncogene

Oncogenic AgentApoptosisP53 ExpressionCell DeathOsteosarcoma Cell Line +7

Nrf2 transactivator-independent GSTP1-1 expression in `GSTP1-1 positive' single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells

Kimihiko Satoh, Ken Itoh, Masayuki Yamamoto, +7

Carcinogenesis

Lipid PeroxidationPathologyCell DeathSingle CellsOxidative Stress +14

Induction of apoptosis but not G1 arrest by expression of the wild-type p53 gene in small cell lung carcinoma.

Jun-ichi Adachi, Keizou Ookawa, Masayuki Shiseki, +4

PubMed

G1 ArrestApoptosisCell DeathPathologyCancer Biology +17