Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

Nisha Padmanabhan, Dongxin Jia, Colleen Geary-Joo, +8

Cell

ChromatinTransgenerational EffectsDevelopmental BiologyGenetic DisorderMedicine +8

Identification of the gene responsible for the <i>cblA</i> complementation group of vitamin B ₁₂ -responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements

Chris Dobson, Timothy Wai, Daniel Leclerc, +6

Proceedings of the National Academy of Sciences

Enhanced Secretory Production of a Single-Chain Antibody Fragment from <i>Bacillus subtilis</i> by Coproduction of Molecular Chaperones

Sau‐Ching Wu, Ruiqiong Ye, Xuchu Wu, +2

Journal of Bacteriology

Protein SecretionEngineeringInclusion Body FormationBacteriologyMolecular Biology +15

Structures of the Human GTPase MMAA and Vitamin B12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

D. Sean Froese, Grazyna Kochan, J.R.C. Muniz, +7

Journal of Biological Chemistry

Molecular RegulationHuman Gtpase MmaaMolecular BiologyTheir Complex FormationCbla Complementation Group +16

Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase

C. Lee Elmore, Xuchu Wu, Daniel Leclerc, +8

Molecular Genetics and Metabolism

Energy MetabolismBiochemistryMethionine Synthase ReductasePhysiologyMice Deficient +9

Efficient Production of a Functional Single-Chain Antidigoxin Antibody via an Engineered Bacillus subtilis Expression-Secretion System

Xuchu Wu, Shi‐Chung Ng, Richard I. Near, +1

Nature Biotechnology

BiomanufacturingEngineeringBiotechnologySynthetic BiologyEfficient Production +6

Structure of MMACHC Reveals an Arginine-Rich Pocket and a Domain-Swapped Dimer for Its B₁₂ Processing Function

D. Sean Froese, T. Krojer, Xuchu Wu, +6

Biochemistry

Molecular BiologyMmachc RevealsDomain-swapped DimerArginine-rich PocketMolecular Design +14

Engineering of Plasmin-Resistant Forms of Streptokinase and Their Production in <i>Bacillus subtilis</i> : Streptokinase with Longer Functional Half-Life

Xuchu Wu, Ruiqiong Ye, Yanjun Duan, +1

Applied and Environmental Microbiology

Structure of the PCCA Gene and Distribution of Mutations Causing Propionic Acidemia

Eric Campeau, Lourdes R. Desviat, Daniel Leclerc, +4

Molecular Genetics and Metabolism

EngineeringPcca GeneGenetic DisorderMedicineGenetics +7

Homozygous nonsense mutation in the MCEE gene and siRNA suppression of methylmalonyl-CoA epimerase expression: A novel cause of mild methylmalonic aciduria

Chris Dobson, Abigail B. Gradinger, Nicola Longo, +8

Molecular Genetics and Metabolism

Sirna SuppressionGenetic DisorderNatural SciencesGeneticsEpigenetic Change +8