RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists

Hiroki Kakuta, Nobumasa Yakushiji, Ryosuke Shinozaki, +15

ACS Medicinal Chemistry Letters

PharmacotherapyGlucose ToleranceInsulin SignalingRxr Full AgonistsMetabolic Syndrome +15

Mechanism of Retinoid X Receptor Partial Agonistic Action of 1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1<i>H</i>-benzotriazole-5-carboxylic Acid and Structural Development To Increase Potency

Fuminori Ohsawa, Shoya Yamada, Nobumasa Yakushiji, +15

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal ChemistryRetinoid X Receptor +14

Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation

Shuji Fujii, Fuminori Ohsawa, Shoya Yamada, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistryG Protein-coupled Receptor +7

Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers

Fuminori Ohsawa, Ken-ichi Morishita, Shoya Yamada, +2

ACS Medicinal Chemistry Letters

PharmacotherapyMolecular PharmacologyMedicinal ChemistryRxr HeterodimersCell Signaling +16

The Mitochondrial Respiratory Chain Maintains the Photosynthetic Electron Flow in Arabidopsis thaliana Leaves under High-Light Stress

Shoya Yamada, Hiroshi Ozaki, Ko Noguchi

Plant and Cell Physiology

PhotorespirationPhotobiologyMolecular BiologyHigh-light StressMitochondrial Biology +18

RXR Partial Agonist Produced by Side Chain Repositioning of Alkoxy RXR Full Agonist Retains Antitype 2 Diabetes Activity without the Adverse Effects

Kohei Kawata, Ken-ichi Morishita, Mariko Nakayama, +11

Journal of Medicinal Chemistry

PharmacotherapyPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistrySide Chain Repositioning +14

Feasibility of Structural Modification of Retinoid X Receptor Agonists to Separate Blood Glucose-Lowering Action from Adverse Effects: Studies in KKA&lt;sup&gt;y&lt;/sup&gt; Type 2 Diabetes Model Mice

Hiroki Kakuta, Fuminori Ohsawa, Shoya Yamada, +4

Biological and Pharmaceutical Bulletin

Synthesis of ¹¹C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [¹¹C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Imaging Thereof

Osamu Shibahara, Masaki Watanabe, Shoya Yamada, +9

Journal of Medicinal Chemistry

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening

Shoya Yamada, Mayu Kawasaki, Michiko Fujihara, +11

Journal of Medicinal Chemistry

Discovery of a “Gatekeeper” Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers

Masaki Watanabe, Michiko Fujihara, Tomoharu Motoyama, +7

Journal of Medicinal Chemistry