Soluble epoxide hydrolase is a therapeutic target for acute inflammation

Kara Schmelzer, Lukáš Kubala, John W. Newman, +3

Proceedings of the National Academy of Sciences

An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension

John D. Imig, Xueying Zhao, Constantine Z. Zaharis, +6

Hypertension

Soluble Epoxide HydrolaseHypertensionRenal FunctionProvides Renal ProtectionSodium Homeostasis +12

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors

Danyan Xu, Ning Li, Yuxia He, +11

Proceedings of the National Academy of Sciences

Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors

Kara Schmelzer, Bora İnceoğlu, Lukáš Kubala, +4

Proceedings of the National Academy of Sciences

Pain MedicineLipid PeroxidationImmunologyMolecular PainPharmacotherapy +17

Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II–Induced Hypertension

Oliver Jung, Ralf P. Brandes, In-Hae Kim, +5

Hypertension

Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water Solubility

In-Hae Kim, Christophe Morisseau, Takaho Watanabe, +1

Journal of Medicinal Chemistry

Soluble Epoxide Hydrolase Inhibitors Reduce the Development of Atherosclerosis in Apolipoprotein E-Knockout Mouse Model

Arzu Ulu, Benjamin B. Davis, Hsing-Ju Tsai, +6

Journal of Cardiovascular Pharmacology

Vascular DiseaseHyperlipidemiaOxidative StressInflammationMetabolic Syndrome +16

Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling

Péter Pokreisz, Ingrid Fleming, Ladislau Kiss, +14

Hypertension

Acute Lung InjuryLung InflammationHypoxic Pulmonary VasoconstrictionRedox BiologyEpoxygenase Activity +15

Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2

Kosuke Nishi, Huazhang Huang, Shizuo G. Kamita, +3

Archives of Biochemistry and Biophysics

Pyrethroid HydrolysisBiochemistryMedicineLiver PhysiologyToxicology +5

Optimization of Amide-Based Inhibitors of Soluble Epoxide Hydrolase with Improved Water Solubility

In-Hae Kim, Fenton R. Heirtzler, Christophe Morisseau, +3

Journal of Medicinal Chemistry

Experimental PharmacologyEnzymatic ModificationRedox BiologyPharmaceutical ChemistryOxidative Stress +16