Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Bheemarao G. Ugarkar, Jay M. DaRe, Joseph J. Kopcho, +4

Journal of Medicinal Chemistry

Molecular PharmacologyInhibitory ActivityBiochemistryMedicine5-Iodotubercidin Analogues +13

A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demonstrating Unique Molecular Properties

Juergen Schanzer, Katharina Wartha, Rebecca Croasdale, +13

Journal of Biological Chemistry

Human GrowthTargeted InhibitionGlycobiologyImmunologyAntibody Screening +7

Adenosine Kinase Inhibitors. 2. Synthesis, Enzyme Inhibition, and Antiseizure Activity of Diaryltubercidin Analogues

Bheemarao G. Ugarkar, Angelo J. Castellino, Jay M. DaRe, +4

Journal of Medicinal Chemistry

Diaryltubercidin AnaloguesPharmaceutical SciencePharmacotherapyChemical BiologyPharmaceutical Chemistry +15

Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition

Rebecca Croasdale, Katharina Wartha, Juergen Schanzer, +20

Archives of Biochemistry and Biophysics

Igf-1r–egfr AntibodiesMedicineImmunologyTumor ImmunityTetravalent Igg1 +9

XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer

Juergen Schanzer, Katharina Wartha, Ekkehard Moessner, +16

mAbs

Antitumor Activity of a Dual Cytokine/Single-chain Antibody Fusion Protein for Simultaneous Delivery of GM-CSF and IL-2 to Ep-CAM Expressing Tumor Cells

Juergen Schanzer, Iduna Fichtner, Patrick A. Baeuerle, +1

Journal of Immunotherapy

Tumor BiologyCytokineCancer ImmunosurveillanceAntitumor ActivityMedicine +12

Targeting of CD19 By Tafasitamab Does Not Impair CD19 Directed Chimeric Antigen Receptor T Cell Activity in Vitro

Paulina Horvei, Reona Sakemura, Michelle J. Cox, +11

Blood

A human cytokine/single-chain antibody fusion protein for simultaneous delivery of GM-CSF and IL-2 to Ep-CAM overexpressing tumor cells.

Juergen Schanzer, Patrick A. Baeuerle, Torsten Dreier, +1

PubMed

ImmunologyImmune RegulationImmunologic MechanismTumor CellsImmunotherapeutics +14

Tafasitamab mediates killing of B-cell non-Hodgkin’s lymphoma in combination with γδ T cell or allogeneic NK cell therapy

Jung Hyun Her, Dominik Pretscher, Maria Patra-Kneuer, +9

Cancer Immunology Immunotherapy

Mg4101 Nk CellsImmune RegulationImmunologyImmunodominanceImmunoediting +20