Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

Gail D. Lewis Phillips, Guangmin Li, Debra L. Dugger, +14

Cancer Research

Drug TargetingBreast OncologyDisulfide LinkersMedicineImmunology +10

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark, +28

Nature Biotechnology

Medicinal ChemistryImmunocytochemical TechniqueDrug TargetingTherapeutic IndexMedicine +8

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu, +30

Nature Biotechnology

ImmunoengineeringImmunologyBioconjugationAntibody EngineeringImmunotherapeutics +6

Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies

Gail D. Lewis Phillips, Irene S. Figari, B M Fendly, +4

Cancer Immunology Immunotherapy

Anti-p185her2 Monoclonal AntibodiesMedicineImmunologyImmune Checkpoint InhibitorTumor Targeting +7

High Level Escherichia coli Expression and Production of a Bivalent Humanized Antibody Fragment

Paul Carter, Robert F. Kelley, Maria Luı́sa Rodrigues, +11

Nature Biotechnology

EngineeringBiotechnologySynthetic BiologyProtein EngineeringAntibody Engineering +6

Increased physical activity and the growth hormone-IGF-I axis in adolescent males

Alon Eliakim, Jo Anne Brasel, Subburaman Mohan, +2

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Origins of PDZ Domain Ligand Specificity

Nicholas J. Skelton, Michael F. T. Koehler, Kerry Zobel, +6

Journal of Biological Chemistry

Ligand-Mediated Immunofunctional Assay for Quantitation of Growth Hormone-Binding Protein in Human Blood

Lena Carlsson, Ann M. Rowland, Ross Clark, +2

The Journal of Clinical Endocrinology & Metabolism

Immunocytochemical TechniqueImmunologyPathologyGrowth Hormone-binding ProteinGh Receptor +18

HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice

David Finkle, Zhi Ricky Quan, Vida Asghari, +8

Clinical Cancer Research

Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families

Yingnan Zhang, Sherry Yeh, B.A. Appleton, +8

Journal of Biological Chemistry