Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le, Jennifer N. Durham, Kellie N. Smith, +43

Science

Solid TumorsPd-1 BlockadeImmunologyPathologyMismatch Repair Deficiency +14

PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

Kevin C. Soares, Agnieszka A. Rucki, Annie A. Wu, +15

Journal of Immunotherapy

Pd-1/pd-l1 Blockade TogetherPd-l1 Antibody TherapyTumor ImmunologyLigand Pd-l1Pancreatic Cancer +12

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

Noelle R. Jurcak, Agnieszka A. Rucki, Stephen Muth, +9

Gastroenterology

Pancreatic CancerPathologyPancreatic SurgeryOrthotopic Pancreatic TumorsMedicine +4

A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

Bridget P. Keenan, Yvonne M. Saenger, Michel I. Kafrouni, +11

Gastroenterology

Prolong SurvivalAutoimmune DiseaseListeria VaccineT-regulatory CellPathogenesis +9

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Kelly Foley, Agnieszka A. Rucki, Qian Xiao, +13

Science Signaling

ImmunologyPathologyPda CellsCancer BiologyTumor Biology +14

Cancer-Associated Fibroblasts in Pancreatic Cancer Are Reprogrammed by Tumor-Induced Alterations in Genomic DNA Methylation

Qian Xiao, Donger Zhou, Agnieszka A. Rucki, +12

Cancer Research

Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer

Agnieszka A. Rucki, Kelly Foley, Pingbo Zhang, +9

Cancer Research

Tumor Microenvironment ControlsBiological MicroenvironmentsPathologyCancer BiologySonic Hedgehog +15

The DcpS inhibitor RG3039 improves motor function in SMA mice

James P. Van Meerbeke, Rebecca M. Gibbs, Heather L. Plasterer, +13

Human Molecular Genetics

Motor ControlCellular PhysiologyDcps Inhibitor Rg3039Experimental NeuropathologyDegenerative Pathology +17

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Kevin C. Soares, Agnieszka A. Rucki, Victoria Kim, +5

Oncotarget

Dual Inhibition of Hedgehog and c-Met Pathways for Pancreatic Cancer Treatment

Agnieszka A. Rucki, Qian Xiao, Stephen Muth, +7

Molecular Cancer Therapeutics