David Bruce Lackey

Enzyme-catalyzed therapeutic agent (ECTA) design: activation of the antitumor ECTA compound NB1011 by thymidylate synthase11Abbreviations: BVdU, (E)-5-(2-bromovinyl)-2′-deoxyuridine; BVdUMP, (E)-5-(2-bromovinyl)-2′-deoxyuridine 5′-monophosphate; NB1011, (E)-5-(2-bromovinyl)-2′-deoxy-5′-uridyl phenyl l-methoxyalaninylphosphoramidate; COSY, correlated spectroscopy; DCI, direct current ionization; DMF, N,N-dimethylformamide; dUMP, 2′-deoxyuridine 5′-monophosphate; ECTA, enzyme-catalyzed therapeutic agent; 5-FU, 5-fluorouracil; 5-FdUMP, 5-fluoro-2′-deoxyuridine 5′-monophosphate; RFU, relative fluorescence units; THF, N5,N10-methylene tetrahydrofolate; TBDMS, tert-butyldimethylsilyl; and TS, thymidylate synthase (EC 2.1.1.45).

David Bruce Lackey, Michael P. Groziak, Maria V. Sergeeva et al. · Biochemical Pharmacology · 2001 · 38 citations

Pharmacy, Biochemistry, Medicinal Chemistry +13

A Homogeneous Chemiluminescent Assay for Telomerase

David Bruce Lackey · Analytical Biochemistry · 1998 · 23 citations

Life Sciences, Biochemistry, Molecular Biology +5

Isolation and structural determination of a novel TRH-like tripeptide, pyroGlu-Tyr-Pro amide, from alfalfa.

David Bruce Lackey · Journal of Biological Chemistry · 1992 · 22 citations · Full text

Pharmacy, Biochemistry, Chromatographic Analysis +15

Purification of a cysteine endopeptidase which is secreted with bioactive peptides from the epidermal glands of <i>Xenopus laevis</i>

Nigel J. Darby, David Bruce Lackey, Derek G. Smyth · European Journal of Biochemistry · 1991 · 20 citations

Life Sciences, Biochemistry, Enzymology +16

Biochemical synthesis of chirally pure Rp oligonucleotide phosphorothioates

David Bruce Lackey, Jasmin Patel · Biotechnology Letters · 1997 · 11 citations

Natural Sciences, Biochemistry, Chemistry +11