Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor α

Thomas Garrett, Neil M. McKern, Meizhen Lou, +11

Cell

Crystal StructureSignal TransductionReceptor (Biochemistry)Molecular BiologyCell Growth +4

Structure of the insulin receptor ectodomain reveals a folded-over conformation

Neil M. McKern, Michael C. Lawrence, Victor A. Streltsov, +20

Nature

Folded-over ConformationMolecular PhysiologyBiochemistryG Protein-coupled ReceptorProtein Folding +7

Identification of the Epitope for the Epidermal Growth Factor Receptor-specific Monoclonal Antibody 806 Reveals That It Preferentially Recognizes an Untethered Form of the Receptor

Terrance G. Johns, Timothy E. Adams, Jennifer R. Cochran, +14

Journal of Biological Chemistry

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

Meizhen Lou, Thomas Garrett, Neil M. McKern, +7

Proceedings of the National Academy of Sciences

Crystal StructureProtein AssemblyMolecular BiologyInsulin ReceptorInsulin Signaling +15

Identification of a Determinant of Epidermal Growth Factor Receptor Ligand-Binding Specificity Using a Truncated, High-Affinity Form of the Ectodomain

T C Elleman, Teresa Domagała, Neil M. McKern, +15

Biochemistry

Human GrowthGrowth Factor AlphaDermatologyCell GrowthHigh-affinity Form +18

CR1/CR2 Interactions Modulate the Functions of the Cell Surface Epidermal Growth Factor Receptor

Francesca Walker, Suzanne G. Orchard, Robert N. Jorissen, +12

Journal of Biological Chemistry

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Thomas Garrett, Antony W. Burgess, Hui Gan, +25

Proceedings of the National Academy of Sciences

Misfolded RegionTumor BiologyWtegfr BindingAntibody BindingGlioma +13

Molecular Characterization of a Secreted Enzyme with Phospholipase B Activity from <i>Moraxella bovis</i>

Jacinta L. Farn, Richard A. Strugnell, Peter A. Hoyne, +2

Journal of Bacteriology

Mutational analysis of the N-linked glycosylation sites of the human insulin receptor

T C Elleman, Maurice J. Frenkel, Peter A. Hoyne, +7

Biochemical Journal

GlycobiologyMolecular BiologyReceptor BiosynthesisInsulin SignalingHuman Insulin Receptor +16

High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

Peter A. Hoyne, Leah Cosgrove, Neil M. McKern, +4

FEBS Letters

Insulin ReceptorsSoluble IrsSignal TransductionBiochemistryG Protein-coupled Receptor +11