Pamela W. M. Kleikers

From single drug targets to synergistic network pharmacology in ischemic stroke

Ana I. Casas, Ahmed Hassan, Simon J. Larsen et al. · Proceedings of the National Academy of Sciences · 2019 · 244 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

Ana I. Casas, Pamela W. M. Kleikers, Stine Mencl et al. · Proceedings of the National Academy of Sciences · 2017 · 152 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke

Ana I. Casas, Pamela W. M. Kleikers, Friederike Langhauser et al. · Journal of Clinical Investigation · 2019 · 90 citations · Full text

Life Sciences, Neurology, Neuroscience +17

A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection

Friederike Langhauser, Ana I. Casas, Vu-Thao-Vi Dao et al. · npj Systems Biology and Applications · 2018 · 73 citations · Full text

Medicine, Pharmacology, Clinical Pharmacology +15

Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries

Marijke Linschoten, Alicia Uijl, Astrid Schut et al. · European Heart Journal · 2021 · 55 citations · Full text

Medicine, Cardiology, Internal Medicine +14