Analgesic Effect of Morphine Glucuronides

Kyoichi Shimomura, Osamu Kamata, Showa Ueki, +4

The Tohoku Journal of Experimental Medicine

Pain MedicinePharmacotherapyExperimental PharmacologyCross ToleranceFree Morphine +14

Biochemical basis for analgesic activity of morphine-6-glucuronide—I

Hidetoshi Yoshimura, Seiu Îda, Kazuta Oguri, +1

Biochemical Pharmacology

Medicinal ChemistryHealth SciencesBiochemistryPain MedicineNatural Sciences +6

Species difference of site-selective glucuronidation of morphine.

Ching Kuei KUO, Nobumitsu Hanioka, Youichi HOSHIKAWA, +2

Journal of Pharmacobio-Dynamics

PharmacotherapyExperimental PharmacologyMolecular PharmacologyMedicinal ChemistryPharmacological Study +16

Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4

Shuso Takeda, Yuji Ishii, Megumi Iwanaga, +5

Molecular Pharmacology

Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position

Kazuta Oguri, Isomi Yamada-Mori, Junko Shigezane, +2

Life Sciences

BiochemistryG Protein-coupled ReceptorEnhanced BindingMedicineNatural Sciences +9

Simultaneous Expression of Guinea Pig UDP-Glucuronosyltransferase 2B21 and 2B22 in COS-7 Cells enhances UDP-Glucuronosyltransferase 2B21-Catalyzed Morphine-6-Glucuronide Formation

Yuji Ishii, Aya Miyoshi, Ryoichi Watanabe, +8

Molecular Pharmacology

INHIBITION OF UDP-GLUCURONOSYLTRANSFERASE 2B7-CATALYZED MORPHINE GLUCURONIDATION BY KETOCONAZOLE: DUAL MECHANISMS INVOLVING A NOVEL NONCOMPETITIVE MODE

Shuso Takeda, Yurie Kitajima, Yuji Ishii, +4

Drug Metabolism and Disposition

Metabolism of Drugs. LXIX. Studies on the Urinary Metabolites of Morphine in Several Mammalian Species

Kazuta Oguri, Seiu Îda, Hidetoshi Yoshimura, +1

Chemical and Pharmaceutical Bulletin

Experimental PharmacologyFree MorphineUrinary MetabolitesPharmacological StudyConjugated Morphine +15

Chemical synthesis and analgesic effect of morphine ethereal sulfates

Masaaki Mori, Kazuta Oguri, Hidetoshi Yoshimura, +3

Life Sciences

Medicinal ChemistryPain MedicineMorphine Ethereal SulfatesMedicineNatural Sciences +7

Interaction between Cytochrome P450 and Other Drug-Metabolizing Enzymes: Evidence for an Association of CYP1A1 with Microsomal Epoxide Hydrolase and UDP-Glucuronosyltransferase

Ken-ichiro Taura, Hideyuki Yamada, Yukiko Hagino, +3

Biochemical and Biophysical Research Communications

Aldehyde DehydrogenaseMicrosomal Epoxide HydrolaseBiochemistryOther Drug-metabolizing EnzymesMedicine +7