The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

Paola Lembo, Eric Grazzini, Jack Cao, +11

Nature Cell Biology

Signal TransductionBiochemistryFunctional SelectivityG Protein-coupled ReceptorPhysiology +7

Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs

Charlotte Avet, Arturo Mancini, Billy Breton, +17

eLife

New Diarylmethylpiperazines as Potent and Selective Nonpeptidic δ Opioid Receptor Agonists with Increased In Vitro Metabolic Stability

Niklas Plobeck, Daniel Delorme, Zhongyong Wei, +19

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryDelta BindingAbuse Liability Profile +13

A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain

Xiao Yu, Chang Cao, Giovanni Martino, +6

Pain

<i>N,N</i>-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide:  A Novel, Exceptionally Selective, Potent δ Opioid Receptor Agonist with Oral Bioavailability and Its Analogues

Zhongyong Wei, W. A. Brown, Bryan K. Takasaki, +21

Journal of Medicinal Chemistry

Oral BioavailabilityPharmacotherapyExperimental PharmacologyPharmaceutical ChemistryPharmacodynamic Modeling +16

Recovery of homogeneous and functional β2-adrenergic receptors from extracellular baculovirus particles

Thomas P. Loisel, Hervé Ansanay, Stéphane St-Onge, +5

Nature Biotechnology

Molecular PharmacologyExtracellular Baculovirus ParticlesMedicinePhysiologyViral Pathogenesis +4

Novel benzimidazole derivatives as selective CB2 agonists

Daniel Pagé, Élise Balaux, Luc Boisvert, +18

Bioorganic & Medicinal Chemistry Letters

Novel Benzimidazole DerivativesFunctional SelectivityMedicinePharmacological AgentPharmacotherapy +3

New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists

Daniel Pagé, Hua Yang, W. A. Brown, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyFunctional SelectivityMedicinePharmacological AgentPharmacotherapy +2

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

Ricardo Alexandrino Garcia, Bruce R. Ito, John A. Lupisella, +20

JACC Basic to Translational Science

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

Peter S. Gargalovic, Pancras C. Wong, Joelle M. Onorato, +13

Circulation Heart Failure