Recurrent DNMT3A mutations in patients with myelodysplastic syndromes

Matthew J. Walter, Li Ding, Dong Shen, +15

Leukemia

Hematological MalignancyChromatinMedicineGeneticsRecurrent Dnmt3a Mutations +3

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

David A. Russler‐Germain, David H. Spencer, Margaret A. Young, +8

Cancer Cell

Cell RegulationAml DominantlyGenetic DisorderGeneticsWild-type Dnmt3a +8

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

Jeffery M. Klco, David H. Spencer, Chris Miller, +15

Cancer Cell

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaGeneticsHematology +5

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

Sujan Shresta, Debra M. MacIvor, Jonathan W. Heusel, +2

Proceedings of the National Academy of Sciences

Radiation OncologyCell SignalingMedicineApoptosisAutophagy +13

Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.

Anne Moon, T J Ley

Proceedings of the National Academy of Sciences

GeneticsGenomic MechanismDna SequencesEpigeneticsCellular Physiology +22

The Human Mast Cell Chymase Gene (CMA1): Mapping to the Cathepsin G/Granzyme Gene Cluster and Lineage-Restricted Expression

George H. Caughey, Thomas H. Schaumberg, Edward H. Zerweck, +4

Genomics

ImmunogeneticsProtein ExpressionMast Cell DisorderLineage-restricted ExpressionImmunology +6

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice.

Jay L. Grisolano, G M Sclar, T J Ley

Proceedings of the National Academy of Sciences

Developmental BiologyTransgenic Bone MarrowCell SpecializationProtein ExpressionGenetics +13

Structure and function of the murine β-globin locus control region 5′ HS-3

Bruce A. Hug, Anne Moon, T J Ley

Nucleic Acids Research

Globin gene expression in erythroid human fetal liver cells.

T J Ley, Katharine Maloney, Jeffrey I. Gordon, +1

Journal of Clinical Investigation

Globin MrnaGeneticsBlood CellEmbryologyLaboratory Hematology +16

Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia

Elizabeth K. Engle, D. Fisher, Chris Miller, +6

Leukemia

Hematological MalignancyChromatinWhole Genome SequencingMedicineGenetics +10