J. R. Turner

Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans

Janet K. Epp, M L Huber, J. R. Turner et al. · Gene · 1989 · 96 citations

Biosynthesis, Engineering, Biotransformation +12

Synthesis and Evaluation of LY121019, a Member of a Series of Semisynthetic Analogues of the Antifungal Lipopeptide Echinocandin Ba

Manuel Debono, Bernard J. Abbott, J. R. Turner et al. · Annals of the New York Academy of Sciences · 1988 · 74 citations

Synthesis of new analogs of echinocandin B by enzymatic deacylation and chemical reacylation of the echinocandin B peptide: Synthesis of the antifungal agent cilofungin (LY121019).

Manuel Debono, Bernard J. Abbott, D. S. Fukuda et al. · The Journal of Antibiotics · 1989 · 59 citations · Full text

Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis

Mark A. Richardson, S. Kuhstoss, M L Huber et al. · Journal of Bacteriology · 1990 · 52 citations · Full text

Drug Resistance Gene, Engineering, Spiramycin Biosynthetic Genes +18

Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.

A J Kreuzman, J. R. Turner, W K Yeh · Journal of Biological Chemistry · 1988 · 50 citations · Full text

Engineering, Chemical Biology, Enzymatic Modification +18