The Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Protect Neuron-Derived C1300 and Neuro2A Cells from Granzyme B-Induced Apoptosis and CD8 T-Cell Killing

Xianzhi Jiang, Aziz Alami Chentoufi, Chinhui Hsiang, +6

Journal of Virology

The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8 ⁺ T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism

Aziz Alami Chentoufi, Elizabeth Kritzer, Michael V. Tran, +11

Journal of Virology

Adaptive Immune SystemImmunologyViral PathogenesisHsv-1 Latency-associated TranscriptCd4 T Cell Responses +18

Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis

Dale Carpenter, Chinhui Hsiang, Donald J. Brown, +5

Virology

Viral ReplicationApoptosisViral PathogenesisImmunologyCell Death +9

A herpes simplex virus type 1 mutant disrupted for microRNA H2 with increased neurovirulence and rate of reactivation

Xianzhi Jiang, Don Brown, Nelson Osorio, +5

Journal of NeuroVirology

NeurovirologyImmunologyVirologyHerpesvirusesMicrorna H2 +7

Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice

Ling Jin, Dale Carpenter, Megan Moerdyk‐Schauwecker, +5

Journal of NeuroVirology

Viral ReplicationMolecular VirologyPathogenesisImmunologyCellular Flip +8

Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2).

Peggy A Campo, Sonali Das, Chinhui Hsiang, +3

PubMed

Breast OncologyMolecular RegulationCyclin D1Cell CycleCancer Biology +16

Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity

Dale Carpenter, Gail Henderson, Chinhui Hsiang, +4

Microbial Pathogenesis

Point MutationsHsv-1 GeneGeneticsApoptosisCell Death +6

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT)

Dale Carpenter, Chinhui Hsiang, Xianzhi Jiang, +4

Journal of NeuroVirology

Cold-shock-induced ApoptosisLatency-associated TranscriptMolecular VirologyViral PersistenceViral Pathogenesis +8

Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2

Xianzhi Jiang, Don Brown, Nelson Osorio, +3

Journal of NeuroVirology

Mutant Dlat2903Systems BiologyLatency-associated TranscriptMolecular VirologyNeurovirology +9

Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells

Chinhui Hsiang, Daniel S. Straus

Oncogene

Tumor BiologyBreast OncologyOncologyMedicineCell Cycle Arrest +7