Size-Exclusion Chromatography Purification of High-Titer Vesicular Stomatitis Virus G Glycoprotein-Pseudotyped Retrovectors for Cell and Gene Therapy Applications

Julia Transfiguracion, Diana E. Jaalouk, Karim Ghani, +2

Human Gene Therapy

Viral ReplicationSynthetic VirologyImmunologyViral Structural ProteinVirus Structure +15

Efficient Human Hematopoietic Cell Transduction Using RD114- and GALV-Pseudotyped Retroviral Vectors Produced in Suspension and Serum-Free Media

Karim Ghani, Xiuyan Wang, Pedro O. de Campos‐Lima, +4

Human Gene Therapy

Viral ReplicationSynthetic VirologyNeurovirologyMedicineHuman Retrovirus +11

Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer

Pierre-Luc Mercier, Magdalena Bachvarova, Marie Plante, +6

Molecular Oncology

Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media

Karim Ghani, Sylvine Carrondo Cottin, Amine Kamen, +1

Gene Therapy

Viral ReplicationMolecular VirologySynthetic VirologyMedicineHuman Retrovirus +9

Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy

Sylvine Carrondo Cottin, Karim Ghani, Pedro O. de Campos‐Lima, +1

Molecular Cancer

Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells

Adnen Faddaoui, Razan Sheta, Magdalena Bachvarova, +8

Cell Cycle

Grhl2 GeneCell DivisionMedicineCycle ArrestGrhl2 Ablation +12

Retroviral vector production using suspension‐adapted 293GPG cells in a 3L acoustic filter‐based perfusion bioreactor

Karim Ghani, Alain Garnier, Helene Coelho, +3

Biotechnology and Bioengineering

Bystander effect in glioblastoma cells with a predominant cytoplasmic localization of connexin43

Sylvine Carrondo Cottin, Karim Ghani, Manuel Caruso

Cancer Gene Therapy

Neuro-oncologyBystander EffectTumor InnervationGliomaPredominant Cytoplasmic Localization +7

A stable platform for the production of virus-like particles pseudotyped with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein

Sylvie Roy, Karim Ghani, Pedro O. de Campos‐Lima, +1

Virus Research

Virus StructureViral ReplicationSpike ProteinViral PathogenesisImmunology +6

Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells

Karim Ghani, Michael Boivin-Welch, Sylvie Roy, +5

Molecular Therapy — Methods & Clinical Development