Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

Michael Smolinski, Yahao Bu, James L. Clements, +9

Journal of Medicinal Chemistry

Chemoprevention StrategyAction Src SignalingMolecular BiologyTubulin Polymerization InhibitorsCytoskeleton +22

SSeCKS/Gravin/AKAP12 Inhibits Cancer Cell Invasiveness and Chemotaxis by Suppressing a Protein Kinase C- Raf/MEK/ERK Pathway

Bing Su, Yahao Bu, David Engelberg, +1

Journal of Biological Chemistry

SSeCKS Metastasis-Suppressing Activity in MatLyLu Prostate Cancer Cells Correlates with Vascular Endothelial Growth Factor Inhibition

Bing Su, Qiao Zheng, Mary M. Vaughan, +2

Cancer Research

Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations

Sameer Urgaonkar, Kamil Nosol, Ahmed M. Said, +5

Journal of Medicinal Chemistry

Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities

Asal Fallah‐Tafti, Alireza Foroumadi, Rakesh Kumar Tiwari, +6

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)Anticancer ActivitiesBiochemistryMedicine +9

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion

Sanjay Sachdev, Yahao Bu, Irwin H. Gelman

BMC Cancer

Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts

Muralidharan Anbalagan, Alaa M. Ali, Ryan K. Jones, +6

Molecular Cancer Therapeutics

Src KinaseBreast OncologyMedicinePaclitaxel Suppresses GrowthPharmacology +13

v-Src-mediated Down-regulation of SSeCKS Metastasis Suppressor Gene Promoter by the Recruitment of HDAC1 into a USF1-Sp1-Sp3 Complex

Yahao Bu, Irwin H. Gelman

Journal of Biological Chemistry

GeneticsCancer BiologyTumor BiologySignaling PathwayCell Regulation +14

An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization of the cellular responses to novel anti-cancer agents in a prostate cell model

Chengjian Tu, Jun‐Xu Li, Yahao Bu, +2

Journal of Proteomics

Prostate Cell ModelProteomic TechnologyMedicineCancer GenomicsComparative Characterization +7

Role for transcription factor TFII‐I in the suppression of SSeCKS/Gravin/Akap12 transcription by Src

Yahao Bu, Lingqiu Gao, Irwin H. Gelman

International Journal of Cancer

Ssecks/gravin/akap12 TranscriptionTranscriptional RegulationSystems BiologySignal TransductionSignaling Pathway +12