Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

Benjamin J. Lamont, Yazhou Li, Edwin Kwan, +3

Journal of Clinical Investigation

Food IntakeGlucose ToleranceInsulin SignalingGastrointestinal Peptide HormoneIncretin Control +14

Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis

Fuzhen Xia, Xiao‐Dong Gao, Edwin Kwan, +7

Journal of Biological Chemistry

S100A4/Mts1 Produces Murine Pulmonary Artery Changes Resembling Plexogenic Arteriopathy and Is Increased in Human Plexogenic Arteriopathy

Steven C. Greenway, Robert Jan van Suylen, Gideon Du Marchie Sarvaas, +4

American Journal Of Pathology

Vascular DiseasePulmonary CirculationCardiovascular DiseaseHuman Plexogenic ArteriopathyPhysiology +6

Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance

Edwin Kwan, Li Xie, Laura Sheu, +5

Diabetes

Munc18-1 Is Critical for Plasma Membrane Localization of Syntaxin1 but Not of SNAP-25 in PC12 Cells

Lakshmanan Arunachalam, Liping Han, Nardos G. Tassew, +9

Molecular Biology of the Cell

Protein SecretionPlasma Membrane LocalizationMolecular BiologyCytoskeletonCellular Physiology +18

Glucagon-Like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet β-Cells

Edwin Kwan, Herbert Y. Gaisano

Diabetes

Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes Models

Nicole Liadis, Leonardo Salmena, Edwin Kwan, +10

Diabetes

ApoptosisImmunologyImmune RegulationCell DeathVivo Roles +20

Interaction Between Munc13-1 and RIM Is Critical for Glucagon-Like Peptide-1–Mediated Rescue of Exocytotic Defects in Munc13-1–Deficient Pancreatic β-Cells

Edwin Kwan, Li Xie, Laura Sheu, +2

Diabetes

High β-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice

Elodie Masson, Shlomit Koren, Fathima Razik, +5

American Journal of Physiology-Endocrinology and Metabolism

Cellular Redox StatusImmunologyInsulin SignalingOxidative StressMetabolic Syndrome +16

The RalA GTPase Is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells

Jamie Lopez Bernal, Edwin Kwan, Li Xie, +3

Journal of Biological Chemistry