Lai-Ming Ching

Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice.

Lai-Ming Ching, Donald P. Goldsmith, Wayne R. Joseph et al. · PubMed · 1999 · 87 citations

Chemoprevention Strategy, Apoptosis, Immunology +19

Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: a novel approach to cancer therapy.

Wayne R. Joseph, Z Cao, Kathleen G. Mountjoy et al. · PubMed · 1999 · 78 citations

Cancer Therapy, Tnf Synthesis, Chemoprevention Strategy +22

Induction of tumor necrosis factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488).

Lai-Ming Ching, Wayne R. Joseph, Kathryn E. Crosier et al. · PubMed · 1994 · 73 citations

Immunotoxicology, Apoptosis, Immunology +18

Thalidomide metabolites in mice and patients with multiple myeloma.

Jun Lu, Brian D. Palmer, P. Kestell et al. · PubMed · 2003 · 42 citations

Hematological Malignancy, Thalidomide Therapy, Pharmacological Study +15

Effect of flavone acetic acid (NSC 347 512) on splenic cytotoxic effector cells and their role in tumour necrosis

Lai-Ming Ching, Bruce C. Baguley · European Journal of Cancer and Clinical Oncology · 1989 · 23 citations

Inflammation, Tumor Biology, Anti-inflammatory +12