R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

Sacha J. Holland, Alison Pan, Christian Franci, +17

Cancer Research

R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation

Sylvia Braselmann, Vanessa Taylor, H. Zhao, +18

Journal of Pharmacology and Experimental Therapeutics

Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor

Polly Pine, Betty Chang, Nathan Schoettler, +7

Clinical Immunology

InflammationRheumatologyRheumatoid DisorderAnti-inflammatoryAutoimmune Disease +10

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

Frances Rena Bahjat, Polly Pine, Andrea Reitsma, +8

Arthritis & Rheumatism

Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus‐prone mice

Guo‐Min Deng, Lena Liu, Frances Rena Bahjat, +2

Arthritis & Rheumatism

A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-Terminal Kinase-Mediated Gene Expression in Synoviocytes

Hoon‐Suk Cha, David L. Boyle, Tomoyuki Inoue, +4

Journal of Pharmacology and Experimental Therapeutics

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

Ryan M. Young, Ian R. Hardy, Raedun Clarke, +5

Blood

Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells

Sandeep Krishnan, Yuang-Taung Juang, Bhabadeb Chowdhury, +10

The Journal of Immunology

Inhibition of Spleen Tyrosine Kinase Prevents Mast Cell Activation and Airway Hyperresponsiveness

Shigeki Matsubara, Guiming Li, Katsuyuki Takeda, +8

American Journal of Respiratory and Critical Care Medicine

Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.

Marcia I. Dawson, Wan‐Ru Chao, Polly Pine, +7

PubMed

Breast OncologyCell ProliferationCancer BiologyTumor BiologyAll-trans-retinoic Acid +17