K. KOYA

MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.

K. KOYA, Y Li, Handong Wang et al. · PubMed · 1996 · 181 citations

Pathology, Cancer Biology, Tumor Biology +22

Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077.

Josephine S. Modica-Napolitano, K. KOYA, Ellen Weisberg et al. · PubMed · 1996 · 123 citations

Mitophagy, Apoptosis, Pathology +16

In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function.

Ellen Weisberg, K. KOYA, Josephine S. Modica-Napolitano et al. · PubMed · 1996 · 48 citations

Mitochondrial Biology, Cardiovascular Toxicity, Oxidative Stress +21

MKT-077, localized lipophilic cation: antitumor activity against human tumor xenografts serially transplanted into nude mice.

Yohei Chiba, Tetsuro Kubota, M. Watanabe et al. · PubMed · 1998 · 33 citations

Photoactivation enhances the mitochondrial toxicity of the cationic rhodacyanine MKT-077.

Josephine S. Modica-Napolitano, B T Brunelli, K. KOYA et al. · PubMed · 1998 · 32 citations

J/cm2 Visible Light, Photobiology, Molecular Biology +19