Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans.

Kevin Jon Williams, G M Fless, K A Petrie, +3

Journal of Biological Chemistry

Low Density LipoproteinOxysterolLipid SynthesisBiochemistryHeparan Sulfate Proteoglycans +12

The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.

I.V. Fuki, Karsten Kuhn, I R Lomazov, +6

Journal of Clinical Investigation

Proteinlipid InteractionGlycobiologyNovel ReceptorsCytoskeletonLigand Clustering +22

Purification and characterization of a human plasma cholesteryl ester transfer protein.

C B Hesler, T L Swenson, Alan R. Tall

Journal of Biological Chemistry

Lipid AnalysisSolvent ExtractionOxysterolBiochemistryNatural Sciences +12

Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.

Ira Tabas, Y Li, R W Brocia, +3

Journal of Biological Chemistry

InflammationLow Density LipoproteinLipoprotein LipaseBiochemistryPhysiology +11

Monoclonal antibodies to the Mr 74,000 cholesteryl ester transfer protein neutralize all of the cholesteryl ester and triglyceride transfer activities in human plasma.

C B Hesler, Alan R. Tall, T L Swenson, +3

Journal of Biological Chemistry

Monoclonal antibody inhibition of cholesteryl ester transfer protein activity in the rabbit. Effects on lipoprotein composition and high density lipoprotein cholesteryl ester metabolism.

M E Whitlock, T L Swenson, R. Ramakrishnan, +4

Journal of Clinical Investigation

High DensityCe AnalogueMonoclonal Antibody InhibitionOxysterolBiochemistry +10

Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids.

T L Swenson, R W Brocia, Alan R. Tall

Journal of Biological Chemistry

Lipid AnalysisProteinlipid InteractionEngineeringFacilitated Lipid TransferLipid Movement +14

Mechanism of Cholesteryl Ester Transfer Protein Inhibition by a Neutralizing Monoclonal Antibody and Mapping of the Monoclonal Antibody Epitope

T L Swenson, C B Hesler, M L Brown, +7

Journal of Biological Chemistry

Immunocytochemical TechniqueImmunologyImmunodominanceLipid MovementImmunotherapy +20

Lipoprotein lipase modulates net secretory output of apolipoprotein B in vitro. A possible pathophysiologic explanation for familial combined hyperlipidemia.

Kevin Jon Williams, K A Petrie, R W Brocia, +1

Journal of Clinical Investigation

PathologyHyperlipidemiaLipid MovementOxidative StressRapid Reuptake +20

Cholesteryl ester transfer protein is secreted by Hep G2 cells and contains asparagine-linked carbohydrate and sialic acid.

T L Swenson, C B Hesler, C L Bisgaier

Journal of Biological Chemistry

Protein SecretionGlycobiologyMolecular BiologyProtein ExpressionBioanalysis +17