NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy

Junichi Azuma, Masako Ohno, Ryuji Kubota, +8

European Journal of Clinical Pharmacology

Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity.

Masako Ohno, Ichiro Yamaguchi, Itiro Yamamoto, +10

PubMed

Tuberculosis PreventionPathologyPharmacotherapyRifampicin-induced HepatotoxicityToxicological Mechanism +17

Effect of the <i>CYP2D6*10</i> genotype on venlafaxine pharmacokinetics in healthy adult volunteers

Tsuyoshi Fukuda, Isamu Yamamoto, Yuko Nishida, +4

British Journal of Clinical Pharmacology

Circadian variation of the urinary 6β-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity

Masako Ohno, Ikumi Yamaguchi, Tomonobu Ito, +3

European Journal of Clinical Pharmacology

Stress HormoneCircadian VariationMedicinePhysiologyPharmacology +7

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients

Masako Ohno, Akiko Yamamoto, Ayumu Ono, +10

European Journal of Clinical Pharmacology

ThrombosisVenous ThrombosisWarfarin Dose RequirementsCardiovascular DiseaseMedicine +13

CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers

Tsuyoshi Fukuda, Shinya Onishi, Shuichi Fukuen, +9

The Pharmacogenomics Journal

Molecular PharmacologyMedicineHealthy VolunteersClinical PharmacologyPharmacogenomics +5

Dose-escalation study of isoniazid in healthy volunteers with the rapid acetylator genotype of arylamine N-acetyltransferase 2

Ryuji Kubota, Masako Ohno, Tomoko Hasunuma, +2

European Journal of Clinical Pharmacology

Dose-escalation StudyMolecular PharmacologyRapid Acetylator GenotypeHealthy VolunteersPhysiology +3

Specific determination of urinary 6β-hydroxycortisol and cortisol by liquid chromatography–atmospheric pressure chemical ionization mass spectrometry

Masako Ohno, Ikumi Yamaguchi, Kayoko Saiki, +2

Journal of Chromatography B Biomedical Sciences and Applications

Adrenal GlandUrologyMedicineMass SpectrometrySpecific Determination +5

CYP2C19 genotypes and omeprazole metabolism after single and repeated dosing when combined with clarithromycin

Qian Zhou, Isamu Yamamoto, Tsuyoshi Fukuda, +3

European Journal of Clinical Pharmacology

Omeprazole MetabolismMedicineCyp2c19 GenotypesPharmacotherapyPharmacology +1

Creation and characteristics of phosphatidylcholine stationary phases for the chromatographic separation of inorganic anions

Wenzhi Hu, Paul R. Haddad, Kazuhiko Tanaka, +5

Journal of Chromatography A

Inorganic ChemistryInorganic AnionsEngineeringBiochemistrySeparation Science +10