Mutations in SECISBP2 result in abnormal thyroid hormone metabolism

Alexandra M. Dumitrescu, Xiao-Hui Liao, Mohamed S Y Abdullah, +7

Nature Genetics

GeneticsThyroid DiseaseSecisbp2 ResultMolecular BiologyMolecular Genetics +4

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

Debyani Chakravarty, Elmer Santos, Mabel Ryder, +12

Journal of Clinical Investigation

Braf ExpressionPathologyTumor BiologyOncologyConditional Braf Activation +17

Generation of functional thyroid from embryonic stem cells

Francesco Antonica, Dominika Figini Kasprzyk, Robert Opitz, +8

Nature

Embryonic Stem CellDevelopmental BiologyFunctional ThyroidMedicineThyroid Disease +5

Tissue-Specific Thyroid Hormone Deprivation and Excess in Monocarboxylate Transporter (Mct) 8-Deficient Mice

Alexandra M. Dumitrescu, Xiao-Hui Liao, Roy E. Weiss, +2

Endocrinology

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

Caterina Di Cosmo, Xiao-Hui Liao, Alexandra M. Dumitrescu, +3

Journal of Clinical Investigation

Thyroid GlandIodine Deficiency DisordersPublic HealthHuman MetabolismCell Signaling +18

Screen detection of ductal carcinoma in situ and subsequent incidence of invasive interval breast cancers: a retrospective population-based study

Stephen W. Duffy, Amanda Dibden, Dimitrios Michalopoulos, +15

The Lancet Oncology

Oncogenic Kras Requires Simultaneous PI3K Signaling to Induce ERK Activation and Transform Thyroid Epithelial Cells <i>In vivo</i>

Kelly A. Miller, Nicole Yeager, Kristen Baker, +3

Cancer Research

Thyroid TumorsSignal TransductionCell RegulationSignaling PathwayPten Deletion +12

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Georg Sebastian Hönes, Helena Rakov, John G. Logan, +25

Proceedings of the National Academy of Sciences

A Thyroid Hormone Analog with Reduced Dependence on the Monocarboxylate Transporter 8 for Tissue Transport

Caterina Di Cosmo, Xiao-Hui Liao, Alexandra M. Dumitrescu, +2

Endocrinology

Thyroid Hormone AnalogParathyroid HormoneNeurochemistryReduced DependenceThyroid Physiology +16

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

Daniel F. Vatner, Dirk Weismann, Sara A. Beddow, +11

American Journal of Physiology-Endocrinology and Metabolism

Kb-2115 TreatmentFatty Liver DiseaseCaloric RestrictionInsulin SignalingMetabolic Syndrome +20