Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase Akt Pathway Mediates Nitric Oxide-Induced Endothelial Cell Migration and Angiogenesis

Koh Kawasaki, Robert S. Smith, Chung-Ming Hsieh, +3

Molecular and Cellular Biology

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

Masashi Takata, Hirotaka Tanaka, Masahiko Kimura, +6

British Journal of Pharmacology

Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats

Daisuke Mochizuki, Ryuichi Tsujita, Shinji Yamada, +6

Psychopharmacology

Psychoactive DrugPsychiatryNeurophysiologyBehavioral NeuroscienceBehavioural Characterization +11

Discovery of selective PDE4B inhibitors

Kenji Naganuma, Akifumi Omura, Naomi Maekawara, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineRational Drug DesignSelective Pde4b InhibitorsPharmacology +2

Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the wet-dog shakes they mediate, but not frontal cortical β-adrenoceptors

Katsuyuki Takao, Tadashi Nagatani, Yoshihisa Kitamura, +3

European Journal of Pharmacology

Synaptic PlasticityWet-dog ShakesNeurobiological MechanismNeurophysiologyFrontal Cortical β-Adrenoceptors +11

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator

Mitsunori Ishiguro, Koh Kawasaki, Yukiya Suzuki, +9

Neuroscience

AngiogenesisRho KinaseHematologyPathologyHemostasis +9

Fasudil and Ozagrel in Combination Show Neuroprotective Effects on Cerebral Infarction after Murine Middle Cerebral Artery Occlusion

Akihiro Koumura, Junya Hamanaka, Koh Kawasaki, +5

Journal of Pharmacology and Experimental Therapeutics

Increased leukocyte ROCK activity in patients after acute ischemic stroke

Steven K. Feske, Farzaneh A. Sorond, Galen V. Henderson, +6

Brain Research

ThrombosisLeukocyte Rock ActivityIschemic StrokeMedicineHematology +10

Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction

Kazuo Yano, Koh Kawasaki, Tsuyoshi Hattori, +7

European Journal of Pharmacology

Cerebral Vascular RegulationNeurophysiologyCellular NeuroscienceNeuroanatomyPhysiology +13

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage

Shin’ichi Satoh, Asako Hitomi, Ichiro Ikegaki, +5

Brain Research Bulletin

Cell DeathOxidative StressCerebral Vascular RegulationBrain InjuryNeurology +16