PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

Tom Verfaillie, Noemí Rubio, Abhishek D. Garg, +8

Cell Death and Differentiation

Reductive StressMitophagyMitochondrial FunctionCell SignalingApoptosis +8

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

Abhishek D. Garg, Dmitri V. Krysko, Tom Verfaillie, +11

The EMBO Journal

Signal TransductionCalreticulin ExposureBiochemistryAtp SecretionChemoprevention Strategy +9

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

Bo Wang, Paul P. Van Veldhoven, Chantal Brees, +7

Free Radical Biology and Medicine

Mitochondrial FunctionBiochemistryLipid PeroxidationPeroxisome-derived Oxidative StressCultured Mammalian Cells +5

Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage

Michael Dewaele, Wim Martinet, Noemí Rubio, +4

Journal of Cellular and Molecular Medicine

MitophagyApoptosisImmunologyCell DeathReactive Oxygen Species +19

Phototoxicity of Hoechst 33342 in time-lapse fluorescence microscopy

Martin Purschke, Noemí Rubio, Kathryn D. Held, +1

Photochemical & Photobiological Sciences

MicroscopyPhotobiologyPhototoxicityHoechst 33342Light Microscopy +2

5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma

Isabelle Coupienne, Grégory Fettweis, Noemí Rubio, +2

Photochemical & Photobiological Sciences

Neuro-oncologyMedicineApoptosisPathologyCell Death +5

NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy

Isabelle Coupienne, Sébastien Bontems, Michael Dewaele, +5

Biochemical Pharmacology

OptogeneticsNeuro-oncologyHealth SciencesGliomaPhotodynamic Therapy +9

p38MAPK-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2–antioxidant signaling

Noemí Rubio, Julien Verrax, Michael Dewaele, +4

Free Radical Biology and Medicine

Redox SignalingSignal TransductionPhotodynamic TherapyMedicineAutophagy +10

Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species

Noemí Rubio, Isabelle Coupienne, Emmanuel Di Valentin, +4

Autophagy

MitophagyPd StressLipid PeroxidationMolecular BiologyCell Death +20

A p38MAPK/HIF-1 Pathway Initiated by UVB Irradiation Is Required to Induce Noxa and Apoptosis of Human Keratinocytes

Kris Nys, An Van Laethem, Carine Michiels, +4

Journal of Investigative Dermatology

Uvb IrradiationApoptosisPhototoxicityCell DeathHuman Keratinocytes +7