Identification of a plant isoflavonoid that causes biliary atresia

Kristin Lorent, Weilong Gong, Kyung Ah Koo, +11

Science Translational Medicine

The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17

Orith Waisbourd‐Zinman, Hong Koh, Shannon J. Tsai, +9

Hepatology

Ras Promotes Growth by Alternative Splicing-Mediated Inactivation of the KLF6 Tumor Suppressor in Hepatocellular Carcinoma

Steven Yea, Goutham Narla, Xiao Zhao, +12

Gastroenterology

Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish

Xiao Zhao, Kristin Lorent, Benjamin J. Wilkins, +10

Hepatology

Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells

Xiao Zhao, Christopher Monson, Chuan Gao, +4

Developmental Biology

Hepatic OutgrowthCell ProliferationCellular PhysiologyTissue DevelopmentSignaling Pathway +14

Impaired Redox and Protein Homeostasis as Risk Factors and Therapeutic Targets in Toxin-Induced Biliary Atresia

Xiao Zhao, Kristin Lorent, Diana Escobar-Zarate, +10

Gastroenterology

Reductive StressRedox RegulatorLiver PhysiologyPhysiologyLipid Peroxidation +11

Task decomposition strategy based on machine learning for boosting performance and identifying mechanisms in heterogeneous activation of peracetic acid process

Wei Zhuang, Xiao Zhao, Qianqian Luo, +4

Water Research

Artificial IntelligenceProcess DesignChemical EngineeringEngineeringMachine Learning +10

Benzene metabolite 1,2,4-benzenetriol changes DNA methylation and histone acetylation of erythroid-specific genes in K562 cells

Chun-Hong Yu, Yang Li, Xiao Zhao, +5

Archives of Toxicology

ChromatinBiochemistryChromatin RemodelingNatural SciencesEpigenetic Change +12

Molecular cloning and expression analysis of common carp Cyprinus carpio tumor necrosis factor-α

Xiao Zhao, Duo Duan, Xiangru Feng, +9

Fisheries Science

InflammationExpression AnalysisPathogenesisPathologyFish Immunology +6

Synthesis and Structure–Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia

Michelle A. Estrada, Xiao Zhao, Kristin Lorent, +6

ACS Medicinal Chemistry Letters

BiosynthesisBioorganic ChemistryPlant Isoflavonoid BiliatresoneBiochemistryStructure–activity Relationship Study +12