Shashirekha S. Markandaiah

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

Xinmei Wen, Wenzhi Tan, Thomas Westergard et al. · Neuron · 2014 · 545 citations · Full text

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Medicine +8

Inhibiting drug efflux transporters improves efficacy of <scp>ALS</scp> therapeutics

Michael Jablonski, Shashirekha S. Markandaiah, Dena A. Jacob et al. · Annals of Clinical and Translational Neurology · 2014 · 91 citations · Full text

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P‐Glycoprotein) in endothelial cells of the blood–brain barrier in mutant superoxide dismutase 1‐linked amyotrophic lateral sclerosis

Hisham Qosa, Jessica Lichter, Mark Sarlo et al. · Glia · 2016 · 70 citations · Full text

Endothelial Cells, Synaptic Transmission, Neurochemical Biomarkers +21

Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis

Loqman A. Mohamed, Shashirekha S. Markandaiah, Silvia Bonanno et al. · Experimental Neurology · 2019 · 51 citations · Full text

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Molecular Neuroscience +11

A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes

Brandie Morris Verdone, M.E. Cicardi, Xinmei Wen et al. · Scientific Reports · 2022 · 26 citations · Full text