Isolation and Solubilization of Proteins After TRI <scp>zol</scp> ® Extraction of RNA and DNA from Patient Material Following Prolonged Storage

Amanda B. Hummon, Sharlene Lim, Michael J. Difilippantonio, +1

BioTechniques

Molecular BiologyNucleic Acid BiomarkersProtein PurificationNucleic Acid ChemistryBioanalysis +17

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Scott D. Seiwert, Steven W. Andrews, Yutong Jiang, +21

Antimicrobial Agents and Chemotherapy

BiochemistryViral HepatitisMedicineNatural SciencesImmunology +12

Modulation of Survival Motor Neuron Pre-mRNA Splicing by Inhibition of Alternative 3′ Splice Site Pairing

Sharlene Lim, Klemens J. Hertel

Journal of Biological Chemistry

Rna ProcessingTranscriptional RegulationMolecular NeuroscienceAlternative 3′Rna Splicing +7

Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs

Csilla Madocsai, Sharlene Lim, Till Geib, +2

Molecular Therapy

Commitment to Splice Site Pairing Coincides with A Complex Formation

Sharlene Lim, Klemens J. Hertel

Molecular Cell

BiologyPattern FormationNatural SciencesA Complex FormationMolecular Biology +1

Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution

Sharlene Lim, Xiaoli Qin, S. Süsser, +13

Antimicrobial Agents and Chemotherapy

Sequence and Phenotypic Analysis for Resistance Monitoring in Hepatitis C Virus Drug Development: Recommendations From the HCV DRAG

Ann D. Kwong, Isabel Nájera, Jill Bechtel, +25

Gastroenterology

Phenotypic AnalysisDrug Resistance AnalysisHepatologyHepatitis CViral Hepatitis +9

[647] SEQUENCE VARIATION OF NS3/4A IN HCV REPLICONS EXPOSED TO ITMN-191 CONCENTRATIONS ENCOMPASSING THOSE LIKELY TO BE ACHIEVED FOLLOWING CLINICAL DOSING

Scott D. Seiwert, Jin Hon, Sharlene Lim, +3

Journal of Hepatology

Molecular VirologyViral HepatitisPathogenesisImmunologyAntiviral Therapy +4

Antiviral Activity of Danoprevir (ITMN-191/RG7227) in Combination With Pegylated Interferon α-2a and Ribavirin in Patients With Hepatitis C

Nicole Forestier, Dominique Larrey, Patrick Marcellin, +9

The Journal of Infectious Diseases

Danoprevir Monotherapy Decreases Inflammatory Markers in Patients with Chronic Hepatitis C Virus Infection

Caralee Schaefer, Karl Kossen, Sharlene Lim, +5

Antimicrobial Agents and Chemotherapy

InflammationAutoimmune DiseaseHepatitis CHepatologyViral Hepatitis +11