Huajun Yan

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade

Yijiang Shi, Huajun Yan, Patrick Frost et al. · Molecular Cancer Therapeutics · 2005 · 370 citations · Full text

Medicine, Cancer Biology, Pharmacology +14

Combinatorial Signaling in the Specification of Unique Cell Fates

Gail V. Flores, Hong Duan, Huajun Yan et al. · Cell · 2000 · 258 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +14

In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model

Patrick Frost, Farhad Moatamed, Bao Hoang et al. · Blood · 2004 · 188 citations · Full text

Medicine, Oncology, Pharmacology +11

Mechanism by Which Mammalian Target of Rapamycin Inhibitors Sensitize Multiple Myeloma Cells to Dexamethasone-Induced Apoptosis

Huajun Yan, Patrick Frost, Yijiang Shi et al. · Cancer Research · 2006 · 108 citations

Life Sciences, Oncology, Pharmacology +17

Interleukin-6 activates phosphoinositol-3′ kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways

Jung-Hsin Hsu, Yijiang Shi, Patrick Frost et al. · Oncogene · 2004 · 68 citations

Medicine, Cell Biology, Oncology +12