Michael J. Bradley

Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7

Shanhu Hu, Jason Marineau, Nisha Rajagopal et al. · Cancer Research · 2019 · 151 citations

Medicine, Oncology, Pharmacology +15

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate

Xudong Wu, Michael J. Bradley, Yiying Cai et al. · Proceedings of the National Academy of Sciences · 2011 · 115 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Identification of cation-binding sites on actin that drive polymerization and modulate bending stiffness

Hyeran Kang, Michael J. Bradley, Brannon R. McCullough et al. · Proceedings of the National Academy of Sciences · 2012 · 107 citations · Full text

Life Sciences, Biology, Cell Biology +12

Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription

Jenna K. Rimel, Zachary C. Poss, Benjamin Erickson et al. · Genes & Development · 2020 · 87 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7

Jason Marineau, Kristin B. Hamman, Shanhu Hu et al. · Journal of Medicinal Chemistry · 2021 · 84 citations · Full text

Life Sciences, Medicinal Chemistry, Oncology +17