Jan W. Pawlak

Cytotoxic and antitumor activity of 1-nitroacridines as an aftereffect of their interstrand DNA cross-linking.

Katarzyna Pawlak, Jan W. Pawlak, Jerzy Konopa · PubMed · 1984 · 48 citations

Antitumor Activity, Toxic Effects, Molecular Biology +17

The mode of action of cytotoxic and antitumor 1-nitroacridines. III. In vivo interstrand cross-linking of DNA of mammalian or bacterial cells by 1-nitroacridines

Jerzy Konopa, Jan W. Pawlak, Katarzyna Pawlak · Chemico-Biological Interactions · 1983 · 37 citations

Nitrosative Stress, Medicine, Antitumor 1-Nitroacridines +9

The mode of action of cytotoxic and antitumor 1-nitroacridines. I. The 1-nitroacridines do not exert their cytotoxic effects by physicochemical binding with DNA

Katarzyna Pawlak, A Matuszkiewicz, Jan W. Pawlak et al. · Chemico-Biological Interactions · 1983 · 33 citations

Cytotoxic Effects, Medicinal Chemistry, Physicochemical Binding +10

The mode of action of cytotoxic and antitumor 1-nitroacridines. II. In vivo enzyme-mediated covalent binding of a 1-nitroacridine derivative, ledakrin or nitracrine, with DNA and other macromolecules of mammalian or bacterial cells

Jan W. Pawlak, Katarzyna Pawlak, Jerzy Konopa · Chemico-Biological Interactions · 1983 · 28 citations

Medicinal Chemistry, Other Macromolecules, Biochemistry +7

In vitro binding of metabolically activated [14C]-Ledakrin, or 1-nitro-9-14C-(3′-dimethylamino-n-propylamino) acridine, a new antitumor and DNA cross-linking agent, to macromolecules of subcellular fractions isolated from rat liver and HeLa cells

Jan W. Pawlak, Jerzy Konopa · Biochemical Pharmacology · 1979 · 27 citations

Dna Cross-linking Agent, Medicinal Chemistry, Biochemistry +9