Terpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing

Hye Jin Jung, Joong Sup Shim, Jiyong Lee, +8

Journal of Biological Chemistry

ImmunologyCell DeathCellular Oxygen SensingCellular OxygenCancer Biology +16

Design and Biological Evaluation of Novel Tubulin Inhibitors as Antimitotic Agents Using a Pharmacophore Binding Model with Tubulin

Do Yoon Kim, Kyun‐Hwan Kim, Nam Doo Kim, +6

Journal of Medicinal Chemistry

CytoskeletonPharmacotherapyPharmacophore Binding ModelPharmaceutical ChemistryDrug Resistance +19

Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model

Eunyoung Chun, Cheol Han, Jeong Hyeok Yoon, +3

International Journal of Cancer

Cell DeathInhibitory CompoundsCancer BiologyXenografted Nude ModelTumor Biology +17

Identification and characterization of the antimicrobial peptide corresponding to C-terminal β-sheet domain of tenecin 1, an antibacterial protein of larvae of Tenebrio molitor

Keun Hyeung Lee, Sung Yu Hong, Jong Eun Oh, +5

Biochemical Journal

Proteinlipid InteractionProtein SecretionBiochemistryVirulence FactorTenecin 1 +9

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Cheol Han, Soon Kil Ahn, Nam Song Choi, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineHuman Metap-2 +6

Mutational spectrum of the iduronate 2 sulfatase gene in 25 unrelated Korean Hunter syndrome patients: Identification of 13 novel mutations

Chi Hwa Kim, Hye Zin Hwang, Seng Song, +6

Human Mutation

Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation

Kisun Ryu, Nam Doo Kim, Seong Il Choi, +5

Bioorganic & Medicinal Chemistry

Synthetic VirologyMedicineAntiviral Drug DevelopmentAntiviral TherapyHepatitis +9

Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction

Young Hoon Kim, Hojin Choi, Jaekwang Lee, +12

Bioorganic & Medicinal Chemistry Letters

Selective Pde5 InhibitorsPotential TherapeuticsMedicineErectile DysfunctionSexual Dysfunction +4

Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors

Myungsok Oh, Isak Im, Yong Jae Lee, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryVirtual ScreeningHit IdentificationDrug TargetMedicine +8

Structural modeling of V299L and E459K Bcr-Abl mutation, and sequential therapy of tyrosine kinase inhibitors for the compound mutations

Dong‐Ho Kim, Dong‐Wook Kim, Byung‐Sik Cho, +9

Leukemia Research

Drug TargetE459k Bcr-abl MutationMedicineReceptor Tyrosine KinaseRational Drug Design +8