M J de Jonge

Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients.

Diederik F.S. Kehrer, Alex Sparreboom, Jaap Verweij et al. · PubMed · 2001 · 175 citations

Gastrointestinal Pharmacology, Gastroenterology, Pathology +16

Irinotecan (CPT-11) metabolism and disposition in cancer patients.

Alex Sparreboom, M J de Jonge, Peter de Bruijn et al. · PubMed · 1998 · 115 citations

Fecal Excretion, Medicinal Chemistry, Oncology +15

Factors involved in prolongation of the terminal disposition phase of SN-38: clinical and experimental studies.

Diederik F.S. Kehrer, Wataru Yamamoto, Jaco J. Verweij et al. · PubMed · 2000 · 61 citations

Molecular Pharmacology, Biochemistry, Experimental Studies +13

Inter- and intrapatient variability in oral topotecan pharmacokinetics: implications for body-surface area dosage regimens.

Walter J. Loos, Hans Gelderblom, Alex Sparreboom et al. · PubMed · 2000 · 53 citations

Therapeutic Drug Monitoring, Lactone Clearance, Oncology +14

Pharmacokinetics and bioavailability of oral 9-aminocamptothecin capsules in adult patients with solid tumors.

Alex Sparreboom, M J de Jonge, Cornelis J. A. Punt et al. · PubMed · 1998 · 20 citations

Medicinal Chemistry, Oral Bioavailability, Oncology +13