OPA1‐dependent cristae modulation is essential for cellular adaptation to metabolic demand

David A. Patten, Jacob Wong, Mireille Khacho, +10

The EMBO Journal

Energy HomeostasisEnergy MetabolismMolecular PhysiologySignal TransductionBiochemistry +13

Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer

Aleksandra Franovic, Lakshman Gunaratnam, Karlene Smith, +3

Proceedings of the National Academy of Sciences

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

Mireille Khacho, Michelle Tarabay, David A. Patten, +8

Nature Communications

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

David A. Patten, Véronique N. Lafleur, Geneviève Robitaille, +3

Molecular Biology of the Cell

MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions

Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, +10

Cell Death and Disease

Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals

Ghadi Antoun, Fiona McMurray, A. Brianne Thrush, +6

Diabetologia

Metabolic SyndromeBiochemistryMitochondrial FunctionRectus Abdominis MusclePhysiology +9

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation

Lucien Nadeau, David A. Patten, Audrey Caron, +11

Biochimica et Biophysica Acta (BBA) - General Subjects

InflammationEnergy MetabolismSkeletal MuscleCell SignalingMedicine +10

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer

Shawn McGuirk, Yannick Audet-Delage, Matthew G. Annis, +12

eLife

p53 Promotes chemoresponsiveness by regulating hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer

Chae Young Han, David A. Patten, Seung Gee Lee, +4

Molecular Carcinogenesis

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

Georges Kanaan, Bianca Ichim, Lara Gharibeh, +9

Redox Biology