Organic Synthesis with Trialkylphosphine Catalysts. Conjugate Addition of Alcohols to α,β-Unsaturated Alkynic Acid Esters

Junji Inanaga, Yoshiyasu Baba, Takeshi Hanamoto

Chemistry Letters

Asymmetric CatalysisEngineeringCatalytic AmountTrialkylphosphine CatalystsOrganic Chemistry +6

Synthesis of a Tetronic Acid Library Focused on Inhibitors of Tyrosine and Dual-Specificity Protein Phosphatases and Its Evaluation Regarding VHR and Cdc25B Inhibition

Mikiko Sodeoka, Ruriko Sampe, Sachiko Kojima, +4

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetMolecular BiologyLibrary ApproachChemical Biology +16

Discovery of Imidazo[1,2-<i>b</i>]pyridazine Derivatives: Selective and Orally Available Mps1 (TTK) Kinase Inhibitors Exhibiting Remarkable Antiproliferative Activity

Ken‐ichi Kusakabe, Nobuyuki Ide, Yataro Daigo, +22

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineOrally Available Mps1Natural Sciences +11

Structure-Based Design of a Highly Selective Catalytic Site-Directed Inhibitor of Ser/Thr Protein Phosphatase 2B (Calcineurin)

Yoshiyasu Baba, Nozomu Hirukawa, Naoto Tanohira, +1

Journal of the American Chemical Society

Biomolecular Structure PredictionImmunologyMolecular BiologyPharmacotherapyProtein Serine/threonine Phosphatases +19

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial

Yuji Koriyama, Akihiro Hori, Hisanori Ito, +19

Journal of Medicinal Chemistry

Indazole-Based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125)

Ken‐ichi Kusakabe, Nobuyuki Ide, Yataro Daigo, +24

Journal of Medicinal Chemistry

Molecular BiologyPharmacotherapySelective Mps1 InhibitorsIndazole-based PotentTumor Biology +18

Optically active cantharidin analogues possessing selective inhibitory activity on Ser/Thr protein phosphatase 2B (calcineurin): Implications for the binding mode

Yoshiyasu Baba, Nozomu Hirukawa, Mikiko Sodeoka

Bioorganic & Medicinal Chemistry

Binding ModeProtein ChemistryMedicinal ChemistryBiochemistrySelective Inhibitory Activity +8

Structure-activity relationship of cantharidin derivatives to protein phosphatases 1, 2A1, and 2B

Mikiko Sodeoka, Yoshiyasu Baba, Satoko Kobayashi, +1

Bioorganic & Medicinal Chemistry Letters

Protein ChemistryCantharidin DerivativesProtein FunctionBiochemistryNatural Sciences +5

Design, synthesis, and structure–activity relationship of new isobenzofuranone ligands of protein kinase C

Yoshiyasu Baba, Yosuke Ogoshi, Go Hirai, +5

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipCombinatorial ChemistryEngineeringProtein Kinase CBiochemistry +5

Asymmetric Synthesis of a 3-Acyltetronic Acid Derivative, RK-682, and Formation of Its Calcium Salt during Silica Gel Column Chromatography.

Mikiko Sodeoka, Ruriko Sampe, Sachiko Kojima, +3

Chemical and Pharmaceutical Bulletin

ChemistryChemical BiologySilica Gel 60Pharmaceutical ChemistryMolecular Pharmacology +18