Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells

Weihua Wan, Mark S. Albom, Lihui Lü, +13

Blood

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)

Gregory R. Ott, Mangeng Cheng, Keith S. Learn, +22

Journal of Medicinal Chemistry

Tumor BiologyClinical Candidate Cep-37440Lymphoid NeoplasiaOncologyMetabolic Stability +12

CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers

Mangeng Cheng, Matthew R. Quail, Diane E. Gingrich, +13

Molecular Cancer Therapeutics

Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity

Gregory R. Ott, Rabindranath Tripathy, Mangeng Cheng, +13

ACS Medicinal Chemistry Letters

Potent InhibitorKinase InhibitorsAnaplastic Lymphoma KinaseLead Inhibitor 15Tumor Biology +16

2,7-Disubstituted-pyrrolo[2,1-<i>f</i>][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity

Gregory R. Ott, Gregory J. Wells, Tho V. Thieu, +15

Journal of Medicinal Chemistry

Tumor BiologyMedicinal ChemistryDiversity Oriented SynthesisPharmaceutical ChemistryMedicine +13

Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.1^3,7.1^9,13]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene Macrocycles

Henry J. Breslin, Brandon M. Lane, Gregory R. Ott, +8

Journal of Medicinal Chemistry

Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase

Diane E. Gingrich, Joseph G. Lisko, Matthew A. Curry, +14

Journal of Medicinal Chemistry

Tumor BiologyLymphoid NeoplasiaDrug TargetingMedicineReceptor Tyrosine Kinase +12

Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models

Eugen F. Mesaros, Jason P. Burke, Jonathan D. Parrish, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmacological StudyBioavailable Alk InhibitorsMedicineAntitumor Efficacy +9

Advanced Engineering for Cathode in Lithium–Oxygen Batteries: Flexible 3D Hierarchical Porous Architecture Design and Its Functional Modification

Yuanguo Wu, Xingbao Zhu, Weihua Wan, +3

Advanced Functional Materials

Flexible 3DEngineeringAdvanced EngineeringLithium–oxygen BatteriesChemistry +18

Ternary Transition Metal Sulfide as High Real Energy Cathode for Lithium–Sulfur Pouch Cell Under Lean Electrolyte Conditions

Hao Guo, Jing Hu, Huimin Yuan, +14

Small Methods