Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Kathrin Maedler, Frédéric Ris, José Oberholzer, +5

Journal of Clinical Investigation

ImmunologyImmune RegulationCell DeathInsulin SignalingIl-1β Contributes +18

Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

Sarah Ferber, Amir Halkin, Hofit Cohen, +8

Nature Medicine

Insulin GenesMetabolic SyndromeSystems BiologyInduces ExpressionLiver Physiology +10

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

Merav Fraenkel, Mali Ketzinel‐Gilad, Yafa Ariav, +8

Diabetes

Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets

Kathrin Maedler, Giatgen A. Spinas, Roger Lehmann, +4

Diabetes

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Kathrin Maedler, Frédéric Ris, José Oberholzer, +5

Journal of Clinical Investigation

ImmunologyCell DeathInsulin SignalingIl-1β ContributesInflammation +14

Differential Regulation of Glucose Transport and Transporters by Glucose in Vascular Endothelial and Smooth Muscle Cells

Nurit Kaiser, Shlomo Sasson, Edward P. Feener, +6

Diabetes

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes

Etty Bachar-Wikström, Jakob D. Wikström, Yafa Ariav, +4

Diabetes

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

Etti Bachar, Yafa Ariav, Mali Ketzinel‐Gilad, +3

PLoS ONE

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion

Guy Cohen, Yael Riahi, Ofer Shamni, +5

Diabetes

Glucocorticoid Receptors in Rat Thymocytes

Roger W. Turnell, Nurit Kaiser, Richard J. Milholland, +1

Journal of Biological Chemistry

ImmunologyCellular PharmacologyLow Salt PelletTriamcinolone AcetonideGlucocorticoid +17