Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells

Tsutomu Imai, Akiko Horiuchi, Cui-ju Wang, +4

American Journal Of Pathology

Cell RegulationCell SignalingMedicineExtracellular MatrixHypoxia (Medicine) +7

Up-Regulation of Small GTPases, RhoA and RhoC, Is Associated with Tumor Progression in Ovarian Carcinoma

Akiko Horiuchi, Tsutomu Imai, Cui-ju Wang, +4

Laboratory Investigation

Small GtpasesMedicineTumor ProgressionPathologyOvarian Carcinoma +5

Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis

Xiaojun Chen, Akiko Horiuchi, Norihiko Kikuchi, +4

Cancer Science

Type‐specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E‐cadherin

Akiko Hayashi, Akiko Horiuchi, Norihiko Kikuchi, +5

International Journal of Cancer

Expression of hypoxia-inducible factor 1α, hypoxia-inducible factor 2α, and von Hippel–Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1α is an independent prognostic factor in ovarian carcinoma

Ryosuke Osada, Akiko Horiuchi, Norihiko Kikuchi, +6

Human Pathology

Nuclear ExpressionOncologyMedicineHypoxia-inducible Factor 1αCancer Cell Biology +9

Expression of BRCA1 protein in benign, borderline, and malignant epithelial ovarian neoplasms and its relationship to methylation and allelic loss of the <i>BRCA1</i> gene

Cui-ju Wang, Akiko Horiuchi, Tsutomu Imai, +5

The Journal of Pathology

Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression

Junko Yoshida, Akiko Horiuchi, Norihiko Kikuchi, +5

Medical Molecular Morphology

Tumoral PathologyDevelopmental BiologyMedicinePathologyMorphogenesis +8

Elevated expression of E-cadherin and α-, β-, and γ-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas

Tsutomu Imai, Akiko Horiuchi, Tanri Shiozawa, +5

Human Pathology

Tumoral PathologyElevated ExpressionMedicineCancer Cell BiologyPathology +7

Toward understanding the natural history of ovarian carcinoma development: a clinicopathological approach

Akiko Horiuchi, Kazuko Itoh, Motohiko Shimizu, +7

Gynecologic Oncology

Tumoral PathologyMedicineNatural HistoryPathologyGynecology +7

Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: An important autocrine/paracrine factor in tumor progression

Norihiko Kikuchi, Akiko Horiuchi, Ryosuke Osada, +4

Cancer Science