Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

Alejandra Sanjuán-Pla, Iain C. Macaulay, Christina T. Jensen, +22

Nature

ThrombopoiesisDevelopmental BiologyBone Marrow FailurePlatelet-biased Stem CellsBlood Platelet +9

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

Anindita Roy, Gillian Cowan, Adam J. Mead, +20

Proceedings of the National Academy of Sciences

Assessment of the Protective Effect of Imvamune and Acam2000 Vaccines against Aerosolized Monkeypox Virus in Cynomolgus Macaques

Graham Hatch, Victoria Graham, Kevin R. Bewley, +14

Journal of Virology

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

Sidinh Luc, Tiago C. Luís, Hanane Boukarabila, +27

Nature Immunology

Myeloid Lineage PotentialDevelopmental BiologyLymphocyte DevelopmentImmunologyAutoimmunity +4

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

Amit Grover, Elena Mancini, Susan Moore, +6

The Journal of Experimental Medicine

Cell LineageDevelopmental BiologyHealth SciencesImmune Cell DevelopmentMedicine +13

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

Tiago C. Luís, Sidinh Luc, Takuo Mizukami, +21

Nature Immunology

Developmental BiologyAdaptive Immune SystemImmunologyAutoimmunityMedicine +3

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors

Christopher A.G. Booth, Nikolaos Barkas, Wen Hao Neo, +17

Cancer Cell

Runx1 Mutations CollaborateChromatinHematological MalignancyMixed-phenotype Acute LeukemiaGenetics +7

Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD–induced myeloproliferation

Adam J. Mead, Wen Hao Neo, Nikolaos Barkas, +19

The Journal of Experimental Medicine

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

Adam J. Mead, Onima Chowdhury, C. Pecquet, +15

Blood

FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors

Adam J. Mead, Shabnam Kharazi, Deborah Atkinson, +16

Cell Reports

Hematological MalignancyMyeloid DifferentiationCell DivisionMixed-phenotype Acute LeukemiaGenetics +7