John C.R. Randle

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

Woods Wannamaker, Robert M. D. Davies, Mark Namchuk et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 309 citations

IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients

Jeffrey H. Stack, Kevin Beaumont, Paul D. Larsen et al. · The Journal of Immunology · 2005 · 187 citations · Full text

Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy

Teresa Ravizza, Sian‐Marie Lucas, Silvia Balosso et al. · Epilepsia · 2006 · 173 citations · Full text

Opposing α- and β-adrenergic mechanisms mediate dose-dependent actions of noradrenaline on supraoptic vasopressin neurones in vivo

Trevor A. Day, John C.R. Randle, Leo P. Renaud · Brain Research · 1985 · 142 citations

Dose-dependent Actions, Neurophysiology, β-Adrenergic Mechanisms +14

Calcium-dependent potassium conductance in rat supraoptic nucleus neurosecretory neurons

Charles W. Bourque, John C.R. Randle, Leo P. Renaud · Journal of Neurophysiology · 1985 · 127 citations

Synaptic Transmission, Neurotransmitter, Calcium-dependent Potassium Conductance +16